Opdivo contains the active ingredient Nivolumab, which is a cancer drug that affects a patient’s immune system to interfere with the growth and spread of cancer cells in the body.
It is used to treat certain types of cancer, including melanoma (skin cancer), non-small cell lung cancer, bladder cancer, kidney cancer, liver cancer, and lung cancer. head and neck human squamous cell carcinoma, colorectal cancer, classical Hodgkin Lymphoma, and urothelial carcinoma.
How does Nivolumab work?
Active ingredient nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the death-1 (PD-1) best online pharmacy receptor preventing its interaction with PD-L1 and PD-L2. The PD-1 receptor is a negative regulator of best online pharmacy T-cell activity that has been shown to be involved in the control Anti Cancer drugs of T-cell immune responses.
Involvement of PD-1 with the ligands PD-L1 and PD-L2, which are expressed in antigen-presenting cells and possibly expressed by tumor or other cells in the tumor microenvironment , leading to inhibition of T-cell proliferation and cytokine secretion.
Nivolumab enhances T-cell responses, including anti-tumor responses, through blockade of PD-1 binding to the ligands PD-L1 and PD-L2. In syngeneic mouse models, blocking Buy Cancer Medication PD-1 activity resulted in decreased tumor growth.
The combination of nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4)-mediated inhibition leads to improved anti-tumor response in metastatic melanoma. In synthetic murine tumor models, dual blockade of PD-1 and CTLA-4 resulted in synergistic anti-tumor activity.
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